Easy cards
Use this trick to unlock all the cards in one or two games. Once you unlock the Cooperstown Legends and the Pixels, play as the Legends. You will find that within the fifth or sixth inning, every hit equals ten points and maybe more. Constantly hit homeruns and strike out the batters and you should have forty to fifty packs to open after the game. This is the easiest way to finish your card collection and unlock the cheats.

Thom Brennaman's stories
Start a game and allow the controller to remain still. After a few minutes after they have announced the lineups and the starting pitcher, Thom Brennaman will start telling in-depth stories about baseball.

Better franchise or expansion mode teams
Use trades to get rid of your older less talented players for a little better players. Even if the CPU rejects your trade, keep trying continually and it is usually accepted. However, make the trade reasonable, such as B- for a B or B+. If the player you really want just does not seem to want to join your team, try trading for another player who is a bit better, then return to that player you want and try again. Do this every season to keep good young players.

Use the pause technique above before batting. When you see where the ball is going, try your best to get the ball as close to the point of the contact triangle (the part closest to the batter, not the thick part of the triangle). you will usually get homeruns or at least doubles.

Wait until the pitcher's arm is in motion and is coming forward, then swing. If it looks like a bad pitch do not swing. This strategy works most of the time, and works well with players such as Giambi, Bonds, or A-Rod.

Easy runs
Get Barry Bonds to bat in the third spot in the order and play the Cubs. Take control of the Cubs and start walking everyone on purpose until Barry Bonds is up for the second time. Rotate the hitting icon so he  will hit a home run. Make contact and you will hit a grand slam. Repeat this as many times as desired. Note: Do not check the box score after 100 runs or the game will freeze.

Better pitching
The best pitchers have a pitch called a "Slurve" (for example, Mark Burhele of the Chicago White Sox). Also try the "Dominate Curve" with Pedro.

Restore pitcher's energy
In season, franchise or expansion mod, go to the DL, and put any pitcher on the15 day DL. Then take him back into your lineup immediately. He will have recovered all his energy.

Catcher
Use these settings for a better catcher:

Contact: A+
Power: A+
Hitting: A+
Speed: A+
Bunt: D:
Patience: D_
Glove: D:
Range: D:
Arm accuracy: B+
Arm strength: B+

Contact: A+
Power: A+
Hitting: A
Speed: A-
Bunt: B-
Patience: B
Glove: D-
Range: D-
Arm Accuracy: D-
Arm Strength: D-

Or use these settings:

Contact: A+
Power: A+
Hitting: A+
Speed: A+
Bunt: C+
Patience: A+
Glove: D-
Range: D-
Arm Accuracy: D-
Arm Strength: C+
You can also set Bunt to D- with Arm Strength C+.

Or use these settings:

Contact: A+
Power: A+
Hitting: A+
Speed: A+
Bunt: D-
Patience: D-
Glove: C+
Range: C+
Arm Accuracy: C
Arm Strength: C

First or second baseman
Use these settings for a better first or second baseman:

Contact: A
Power: A+
Hitting: A
Speed: A+
Bunt: D:
Patience: D:
Glove: D:
Range: D:
Arm Accuracy: A:
Arm Strength: A:
Overall: A

Infielder
Same as above
Overall: A:

Outfielder
Use these settings for a better outfielder:

Contact: A:
Power: A+
Hitting: A:
Speed: A+
Bunt: D:
Patience: D:
Glove: D:
Range: D:
Arm Accuracy: A
Arm Strength: A
Overall: A-