Play letters for highest score
There are some options that are available on the right hand side of the screen while playing. Just select the "Guides" option, then choose "Suggestions". A box with a list of all the available words you can play with your letters from highest to lowest will be shown. To play the word, just double click on the word of your choice on the list and it will be displayed on the game board. Then, click "Play". You will win most of the time under any difficulty setting against any number of players this also includes CPU opponents.