Cheat mode
Note: v1.1 of the game is needed to enable every code. A few but not all, codes can be used with earlier versions. Note: This cheat involves editing a game file so make a backup copy of the file before going on. Now use a text editor to edit the "defuser.ini" file in the game directory. Set a key binding to the codes below (for example, "F10=fly". Then, press the matching key while playing to activate the desired cheat. Note: Any active codes are disabled when a new area loads or intermission sequence is played.

Hints & Tips

Beating: Frank Fontaine
To beat Frank Fontaine quickly, when you first go into the room hit him with the tool the Little Sisters gave you. Fight him when he throws you off. When he is back on the bed, run up and hit him again with the tool to drain his Adam. This will work a lot faster due to him only having four or five jars of Adam to drain, and the fights are not long afterwards.

Beating Peach Wilkins
When the dark cloud envelopes the icy battlefield upon which you have to face Peach Wilkins, save your game and find the hostile turret at the end of the room when the cloud clears. Load your game and run to it before the cloud clears, so that you can freeze or shock it. Then, hack it so it shoots your enemies. Crouch down by the area to your right when facing the turret. There are a few barriers here to protect you from the enemy fire. But, to avoid damage by Wilkins' grenades, keep Telekinesis as your active Plasmid. He will avoid the turret's fire, but as long as you remain behind the barriers by the turret he will stay at a safe distance. This gives you time to return his grenades using Telekinesis until he dies. The turret will take out most of the Splicers. This way makes things easier because it eliminates the hectic "run around and whack people with the wrench" strategy that is otherwise your only choice. That turret if not used as an ally would probably be the main cause of your death, along with the bots triggered by the security camera. By hiding near the allied turret but, you also hide from the camera's view.

Restore hacked robot's health
After you hack a robot, it will start to fire at your enemies. If the robot gets hit it will begin to lose health, catch on fire, and blow up in time. To stop this from occuring, deactivate the robot, then reactivate it in a few seconds. This should make the robot have full health.

Beating Atlas Fontaine
This is the last Boss and he has three different styles of attacks:. Flame Plasmid Form, Ice Plasmid Form, and Electric Plasmid Form. The easiest way to beat him in the first part is to use your Ice Plasmid and freeze him. Then, switch to your Telekinesis Plasmid. Grab an explosive tank and throw it towards him. Also, if you like use your telekinesis. He is predictable if you are far away from him. Wait for him to throw a fire ball at you then move out of it's way. He will continue to run past you. Now use this chance to fire the machine gun, which does the most damage. When he goes back to his chamber to gain his life back, change to the Flame Plasmid and be ready for a few bots. When he starts his routine of fire and run, blast again him with the Flame Plasmid. The more you blast him, the quicker he loses life. Continue to use the machine gun while he is on fire. He will now go back to his chamber one final time. He now has electrical powers. Keep your Flame Plasmid ready. This time, shoot him with the Flame Plasmid and he will run for the water. When he jumps in the water and comes out, hit him with it again. Be aware that there are splicers all over also. Also set them ablaze to receive some extra life. There are several ways to beat him.

Beating Rosies
When your fighting a Rosie, use armor piercing rounds from the machine gun or pistol. For a really effective way of killing, launch frag grenades and run out a door. The Rosie will follow you, fire mines at the door, and when it walks through it will be damaged or destroyed.

Beating security robots
If you are up against a stationary security robot, use Telekenesis to grab a crate or pallet. Now hold it in front of you until you can find a place to hide and plan what to do. The item you hold up will block a few attacks.

Weapon Upgrade Station locations

1: In Peach Wilkins' hideout (Neptune's Bounty), bottom floor. As soon as you come downstairs it is directly in front of you.

2: On the way to Farmer's Market in Arcadia, the station is located to the left after you go up the first stairs coming from Tree Farm.

3: The Winery's basement in Farmer's Market. There is a flooded area with one of them attached to the wall. It is in front of you when you come down the stairs; just keep going forward.

4: In Fort Frolic, from the Atrium bottom floor, go towards the bathrooms. Then, move right and follow the path until you see some small stairs to your right leading up to a door. Go inside then go down into the basement. The basement is filled with cigars and the like. The upgrade station is on the wall.

5: Go to Poseidon Plaza in Fort Frolic. Go to the other end of the bottom floor (the opposite end of where you enter). Go into Sinclair Spirits (the room that has a corpse on a sort of "altar"). In the basement of this store is the station.

6: In Hephaestus Core Room, go down to the bottom floor and run around (literary). Eventually you will see it attached to the wall.

7: In Hephaestus, Kyburz's office. It is attached to the left wall (back turned to the entrance) in the rear of the room.

8: At the bottom floor of the Mercury Suites area, on the back of the center pillar.

9: In Sander Cohen's secret room, in the Olympus Heights' Mercury Suites area.

10: Go to Atlas' Headquarters in Apollo Square (Fontaine's Home For The Poor area). It is located on the fourth floor. Go down the stairs in the room and look to the right. The station will be in front of you.

11: When you enter Point Prometheus and chase Fontaine, eventually you will end up in a little square and Fontaine will go behind a locked Museum door. At the opposite end of this square (from where you came) is a dead Big Daddy. Next to it is the upgrade.

12: In the Voice changing labs in Point Prometheus, one of the labs has it.

Tonic locations

Medical Pavilion
1. Security Expert: On a shelf in the Twilight Fields mortuary.

2. Speedy Hacker: In the corner of Painless Dental.

3. Wrench Jockey: In Kure All, through the crawl shaft on the floor.

4. Hacker's Delight: Activate the furnace in the Eternal Flame Crematory.

5. Static Discharge: In the Surgery Foyer next to Steinman's lab.

6. Eve Link: Purchased at Gatherer's Garden.

7. Armored Shell: Purchased at Gatherer's Garden.

Neptune's Bounty
8. Wrench Lurker: Lower Wharf, near the edge of the walkway (after you get the camera.)

9. Focused Hacker: Inside Fontaine Fisheries, next to first pneumo tube.

10. Medical Expert: On the lower Wharf as you enter the level.

11. Extra Nutrition: Purchased at Gatherer's Garden.

Arcadia
12. Security Evasion: On the lower left area of Arcadia. It will be next to a dead Houdini Splicer that is surrounded by four Thuggish Splicers.

13. Hacking Expert: On the desk as you enter the Research Laboratories.

14. Shorten Alarms: Purchased at Gatherer's Garden.

15. Human Inferno: Purchased at Gatherer's Garden.

Farmer's Market
16. Eve Link 2: To the left of the entrance near the Circus Of Value and U-Invent machine.

17. Photographers Eye: In the bunk of the bottom floor of the winery.

Fort Frolic
18. Alarm Expert: On the balcony of the fleet Hall. Jump to it from the balcony next to it.

19. Frozen Field: Search Matin Finnegan's corpse.

20. Extra Nutrition 2: Down the stairs behind the main stairway of the main atrium near Eve's Garden.

21. Electric Flesh: In Cohen's dressing room. Must complete his masterpiece, then go to the room next to the upstairs projection booth.

22. Medical Expert 2: Unlocked by Sander after you complete his masterpiece.

23. Hacking Expert 2: Purchased at Gatherer's Garden.

24. Bloodlust: Must be invented in the U-Invent machine.

25. Booze Hound: Must be invented in the U-Invent machine.

26. Hacker's Delight 2: Must be invented in the U-Invent machine.

Hephaestus
27. Frozen Field 2: On a desk in the bottom corner of the central core.

28. Security Evasion 2: In Lower Heat Loss Monitoring on a desk.

29. Damage Research: Secret crawlspace in the back of the lower workshops.

30. Shorten Alarms 2: Geothermal core (after you deploy the bomb).

Olympus Heights
31. Clever Inventor: On a desk in Suchong's Apartment.

32. Electric Flesh 2: On a desk in Fontaine's Apartment.

33. Speedy Hacker 2: Purchased at Gatherer's Garden.

34. Wrench Lurker 2: Purchased at Gatherer's Garden.

Apollo Square
35. Medical Expert 3: Second floor of Suchong's clinic.

36. Focused Hacker 2: Fourth floor of the Hestia building.

Point Prometheus
37. Safe Cracker 2: Autopsy room of the first floor of Little Wonders.

38. Alarm Expert 2: On a filing cabinet in Point Prometheus.

39. Damage Research 2: On a desk in the second floor library.

40. Hacker's Delight 3: Next to Rosie helmets in Failsafe Armory.

41. Human Inferno 2: Purchased at Gatherer's Garden.

Tenenbaum Gifts
42. Safecracker: Rescue 6 Little sisters.

43. Armored Shell 2: Rescue 15 Little sisters.

44. Prolific Inventor: Rescue 18 Little sisters.

Research Bonuses
45. Natural Camoflage: Research level 2 Houdini Splicers.

46. Scrounger: Research level 2 Leadhead Splicers.

47. Sportboost: Research level 2 Thuggish Splicer.

48. Photographer's Eye 2: Research level 2 Rosie.

49. Wrench Jockey 2: Research level 2 Bouncer.

50. Extra Nutrition 3: Research level 4 Spider Splicer.

51. Sportboost 2: Research level 4 Thuggish Splicer.

52. Static Discharge 2: Research level 4 Leadhead Splicer.

53. Security Expert 2 : Research level 2 Security Bot.

Audio Dairy locations
Here is a list of the 122 audio diaries.